2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N7345
    Schizandriside 71222-06-5 98%
    Schizandriside is a cerebroside, which can be isolated from Uvaria tonkinensis var..
    Schizandriside
  • HY-N7437
    Akuammidine 639-36-1 98%
    Akuammidine, isolated from the seeds of Picralima nitida, shows a preference for μ-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 μM at μ-, σ- and κ-opioid binding sites, respectively. Akuammidine possesses anti-inflammatory and anti-asthmatic properties.
    Akuammidine
  • HY-N7506
    13-Hydroxyisobakuchiol 178765-49-6 98%
    Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) isolated from Psoralea corylifolia (L.), is a potent monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC50=0.58 μM) and norepinephrine transporter (NET) (IC50=0.69 μM) than for the serotonin transporter (SERT) (IC50=312.02 μM). 13-Hydroxyisobakuchiol has the potential for the research of disorders such as Parkinson's disease and depression.
    13-Hydroxyisobakuchiol
  • HY-N7527
    Baccatin VI 57672-79-4 98%
    Baccatin VI is a natural taxoid with antinociceptive activities. Baccatin VI possesses significant antinociceptive activity against p-Benzoquinone-induced abdominal contractions.
    Baccatin VI
  • HY-N7555
    Valeriotetrate C 904891-20-9 98%
    Valeriotetrate C, a compound isolated from Valeriana jatamansi Jones, exhibits neuroprotective activity.
    Valeriotetrate C
  • HY-N7603
    Rubrofusarin triglucoside 245724-07-6 98%
    Rubrofusarin triglucoside is a glycoside compound isolated from Cassia obtusifolia Linn seeds. Rubrofusarin triglucoside inhibits human monoamine oxidase A (hMAO-A) with an IC50 of 85.5 μM.
    Rubrofusarin triglucoside
  • HY-N7708
    Lycodoline 6900-92-1 98%
    Lycodoline is a alkaloid with butyrylcholinesterase (BChE) (IC50 of 667 μM) inhibition activities.
    Lycodoline
  • HY-N7751
    Isotanshinone II 98249-39-9 98%
    Isotanshinone II is a natural product that can be isolated from Salvia glutinos. Isotanshinone II can be used to study Alzheimer's disease.
    Isotanshinone II
  • HY-N7780
    Aflatrem 70553-75-2 98%
    Aflatrem is a mycotoxin that can be isolated from Aspergillus flavus. Aflatrem has acute neurotoxic effects and can be ued in neurological disease.
    Aflatrem
  • HY-N7965
    Methyl kakuol 70342-29-9 98%
    Methyl kakuol shows agonistic activity against TRPA1 with an EC50 of 0.27 µM.
    Methyl kakuol
  • HY-N7966
    Bacopaside N2 871706-75-1 98%
    Bacopaside N2 is a diglycosidic saponin.
    Bacopaside N2
  • HY-N8018
    Leucosceptoside A 83529-62-8 98%
    Leucosceptoside A is a phenylethanoid glycoside with anti-hyperglycemic and anti-hypertensive activities. Leucosceptoside A shows inhibitory activity against α-glucosidase and PKCα (IC50 of 19.0 μM).
    Leucosceptoside A
  • HY-N8103
    Heishuixiecaoline A 1469493-85-3 98%
    Heishuixiecaoline A is a germacrane-type sesquiterpenoid. Heishuixiecaoline A shows protective effect on the neurotoxicity of PC12 cells induced by Aβ25-35.
    Heishuixiecaoline A
  • HY-N8216
    Bacopaside IV 155545-03-2 98%
    Bacopaside IV is a saponin.
    Bacopaside IV
  • HY-N8222
    Bacopaside N1 871706-74-0 98%
    Bacopaside N1 is a diglycosidic saponin.
    Bacopaside N1
  • HY-N8260
    Angeloylgomisin Q 72561-28-5 ≥98.0%
    Angeloylgomisin Q is a new dibenzocyclooctadiene lignan from the stems of Schisandra sphaerandra. Angeloylgomisin Q has the potential for alzheimer's disease research.
    Angeloylgomisin Q
  • HY-N8315
    Echitovenidine 7222-35-7 98%
    Echitovenidine is an alkaloid that can be isolated from Alstonia yunnanensis. Echitovenidine is an inhibitor of monoamine oxidase (MAO).
    Echitovenidine
  • HY-N8412
    4-O-Methylbutein 13323-67-6 98%
    4-O-Methylbutein is a phenolic glucoside that can be isolated from Elsholtzia ciliata.4-O-Methylbutein exhibits neuroprotective effects against glutamate-induced HT22 cell death with an EC50 of 35.2 μM.
    4-O-Methylbutein
  • HY-N8414
    Dehydrogeijerin 16850-91-2 98%
    Dehydrogeijerin is an inhibitor of acetylcholinesterase with an IC50 of 9.7 μM. Dehydrogeijerin can be used in study Alzheimer’s disease.
    Dehydrogeijerin
  • HY-N8422
    1(10)-Aristolen-2-one 28398-06-3 98%
    1(10)-Aristolen-2-one is an agent with sedative effect.
    1(10)-Aristolen-2-one
Cat. No. Product Name / Synonyms Application Reactivity